Yoshinori Okada Selected Research

3- ((4- (4- chlorophenyl)piperazin- 1- yl)methyl)- 1H- pyrrolo(2,3- b)pyridine

6/2008	A dopamine receptor antagonist L-745,870 suppresses microglia activation in spinal cord and mitigates the progression in ALS model mice.
7/2005	A dopamine D4 receptor antagonist attenuates ischemia-induced neuronal cell damage via upregulation of neuronal apoptosis inhibitory protein.

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Yoshinori Okada Research Topics

Disease

20	Neoplasms (Cancer) 02/2022 - 02/2003
19	Lung Neoplasms (Lung Cancer) 02/2022 - 08/2003
14	Lymphangioleiomyomatosis (Lymphangiomyomatosis) 02/2022 - 12/2010
11	Chronic Obstructive Pulmonary Disease (COPD) 01/2022 - 12/2003
11	Adenocarcinoma of Lung 05/2021 - 11/2013
10	Infections 04/2022 - 12/2003
10	Pulmonary Hypertension 01/2022 - 11/2004
8	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2022 - 06/2018
8	Pneumothorax 11/2020 - 12/2010
7	Lung Diseases (Lung Disease) 11/2021 - 12/2003
7	Inflammation (Inflammations) 10/2019 - 03/2010
6	Hypoxia (Hypoxemia) 10/2019 - 08/2013
5	Interstitial Lung Diseases (Interstitial Lung Disease) 04/2021 - 01/2017
5	Primary Graft Dysfunction 01/2020 - 12/2009
5	Reperfusion Injury 01/2018 - 02/2006
4	Respiratory Insufficiency (Respiratory Failure) 02/2022 - 01/2016
4	Dyspnea (Shortness of Breath) 02/2022 - 01/2020
4	Neoplasm Metastasis (Metastasis) 01/2022 - 02/2010
4	Carcinogenesis 01/2021 - 08/2003
4	Adenocarcinoma 03/2020 - 08/2003
4	Alzheimer Disease (Alzheimer's Disease) 08/2019 - 04/2013
4	Ischemia 01/2018 - 07/2005
4	Pulmonary Arterial Hypertension 01/2018 - 11/2008
3	Esophageal Neoplasms (Esophageal Cancer) 01/2022 - 07/2010
3	Pleural Effusion (Pleural Effusions) 12/2021 - 02/2017
3	Emphysema 08/2021 - 10/2017
3	Pneumonia (Pneumonitis) 05/2021 - 10/2007
3	Critical Illness (Critically Ill) 06/2020 - 04/2013
3	Lung Injury 01/2018 - 12/2009
3	Edema (Dropsy) 01/2016 - 03/2010
3	Brain Death (Brain Dead) 08/2015 - 04/2013
3	Bronchiolitis Obliterans 04/2014 - 10/2003
2	Eisenmenger Complex (Eisenmenger's Syndrome) 01/2022 - 07/2013
2	Fibrosis (Cirrhosis) 01/2022 - 01/2017
2	Idiopathic Pulmonary Fibrosis 08/2021 - 01/2011
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2020 - 08/2003
2	Pulmonary Alveolar Proteinosis 01/2020 - 01/2017
2	Disease Progression 04/2019 - 06/2008
2	Carcinoma (Carcinomatosis) 02/2019 - 08/2003
2	Chylothorax 10/2018 - 02/2017
2	Virus Diseases (Viral Diseases) 01/2018 - 09/2016
2	Liver Cirrhosis (Hepatic Cirrhosis) 12/2017 - 01/2016
2	Thrombosis (Thrombus) 12/2016 - 06/2016
2	Cysts 04/2016 - 07/2010
2	Pain (Aches) 01/2016 - 07/2009
2	Familial Primary Pulmonary Hypertension 05/2015 - 11/2004
2	Glioma (Gliomas) 01/2014 - 10/2011
2	Vascular Remodeling 08/2013 - 12/2005

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2003
10	lipoarabinomannan (LAM)IBA 02/2022 - 12/2010
10	ErbB Receptors (EGF Receptor)IBA 05/2021 - 11/2013
7	Messenger RNA (mRNA)IBA 01/2022 - 08/2003
5	Tyrosine Kinase InhibitorsIBA 05/2021 - 11/2013
4	SteroidsIBA 05/2021 - 07/2009
3	Anesthetics (Anesthetic Agents)IBA 08/2021 - 07/2011
3	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 12/2018
3	Sirolimus (Rapamycin)FDA Link 08/2020 - 02/2018
3	EnzymesIBA 01/2018 - 07/2011
3	CytokinesIBA 01/2018 - 03/2010
3	AntioxidantsIBA 01/2018 - 08/2013
2	Immune Checkpoint InhibitorsIBA 02/2022 - 03/2019
2	LigandsIBA 01/2022 - 05/2005
2	Immunoglobulins (Immunoglobulin)IBA 01/2022 - 08/2021
2	Pancreatic Elastase (Elastase)IBA 08/2021 - 10/2017
2	Propofol (Diprivan)FDA LinkGeneric 08/2021 - 07/2009
2	Phosphates (Orthophosphate)IBA 01/2021 - 01/2015
2	Tacrolimus (Prograf)FDA LinkGeneric 12/2020 - 10/2019
2	Surface-Active Agents (Surfactants)IBA 01/2020 - 01/2017
2	Indicators and Reagents (Reagents)IBA 11/2019 - 12/2016
2	Phosphotransferases (Kinase)IBA 11/2019 - 07/2011
2	Immunosuppressive Agents (Immunosuppressants)IBA 10/2019 - 01/2016
2	Amyloid (Amyloid Fibrils)IBA 08/2019 - 04/2013
2	PeriostinIBA 08/2019 - 07/2018
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 06/2018 - 04/2016
2	Biomarkers (Surrogate Marker)IBA 06/2018 - 01/2018
2	TOR Serine-Threonine KinasesIBA 02/2018 - 11/2015
2	Alprostadil (Muse)FDA LinkGeneric 01/2018 - 01/2018
2	Hydrogen Peroxide (Hydroperoxide)FDA LinkGeneric 01/2018 - 01/2014
2	Poly I-CIBA 01/2018 - 09/2016
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 10/2017 - 10/2003
2	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2016 - 01/2014
2	Endoplasmic Reticulum Chaperone BiPIBA 01/2014 - 10/2011

Therapy/Procedure

41	Lung Transplantation 04/2022 - 10/2003
16	Therapeutics 10/2021 - 12/2003
8	Transplantation 04/2022 - 12/2004
5	Extracorporeal Membrane Oxygenation 01/2022 - 04/2014
5	Pneumonectomy (Lung Volume Reduction) 04/2021 - 07/2010
4	Radiotherapy 01/2021 - 02/2010
4	Operative Surgical Procedures 10/2020 - 12/2010
4	Pleurodesis 10/2018 - 12/2010
3	Esophagectomy 01/2022 - 07/2010
3	Sternotomy 04/2021 - 02/2010
3	Lymph Node Excision (Lymph Node Dissection) 01/2016 - 02/2003
2	Epidural Anesthesia 10/2021 - 06/2011
2	Organ Transplantation 08/2020 - 10/2019
2	Chest Tubes (Chest Tube) 10/2018 - 08/2013
2	Warm Ischemia 01/2018 - 01/2015
2	Thoracostomy 05/2016 - 02/2012
2	Negative-Pressure Wound Therapy 05/2016 - 02/2012
2	Heart-Lung Transplantation 10/2014 - 11/2008